By Jose de Leon (auth.), Jose de Leon (eds.)
Emotional, behavioral, and neuropsychiatric stipulations are universal in people with highbrow disabilities (IDs), so much significantly epilepsy, aggression, self-injurious behaviors, and bipolar and different temper problems. regardless of the superiority of such difficulties, there's a shortage within the literature of trustworthy info on scientific remedies for people with IDs.
A Practitioner's consultant to Prescribing Antiepileptics and temper Stabilizers for Adults with highbrow Disabilities presents an in depth framework for prescribing for this hard inhabitants. that includes the main updated info on elements that tell prescribing, the Guide addresses easy concerns and controversies (e.g., the rift among evidence-based and custom-made drugs) in treating adults with cognitive deficits. consumers' particular wishes are emphasised in constructing applicable and powerful pharmacological intervention for better results and caliber of lifestyles. medications mentioned within the Guide contain carbamazepine, clonazepam, diazepam, ethosuximide, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, lithium, lorazepam, oxcarbazepine, phenobarbital, phenytoin, pregabalin, primidone, rufinamide, tiagabine, topiramate, valproate, and zonisamide. for every of those compounds, the tips cover:
- Indications to be used; relative and absolute contraindications.
- Assessment in the course of therapy; healing drug tracking; indications and signs for caretakers.
- Dosage: management; preliminary and greatest instructed dosage; ameliorations linked to drug-drug interactions, own features, and (where applicable) genetic variations.
- Adverse drug reactions: universal, quite unusual, and in all likelihood deadly, plus possibility of metabolic syndrome.
- Guidelines for discontinuation.
- References, tables, and drug usage reviews.
A Practitioner's advisor to Prescribing Antiepileptics and temper Stabilizers for Adults with highbrow Disabilities is an essential decision-making reference for psychiatrists, neuropsychologists, psychopharmacologists, neurologists, internists, and medical psychologists.
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Additional info for A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities
The Appendix describes the carbamazepine drug utilization review that summarizes this guideline. 1 Indications for Use Epilepsy (Partial in Onset With or Without Secondary Generalization) Meta-analyses of randomized monotherapy controlled trials indicated that carbamazepine (1) may be less likely to be withdrawn than phenobarbital (Tudur Smith et al. 2003); (2) has no differences in outcomes than phenytoin (Tudur Smith et al. 2002) or oxcarbazepine (Koch and Polman 2009); (3) may be better in partial epilepsy than valproate, but there was no evidence that valproate was better in generalized epilepsy (Marson et al.
The British Journal of Psychiatry, 137, 469–474. References 13 Davanzo, P. , & King, B. H. (1996). Open trial lamotrigine in the treatment of self-injurious behavior in an adolescent with profound mental retardation. Journal of Child and Adolescent Psychopharmacology, 6, 273–279. de Leon, J. (2008). The potential of genotyping (letter). Science, 321, 769. de Leon, J. (2009). The future (or lack of future) of personalized prescription in psychiatry. Pharmacological Research, 59, 81–89. , & Singh, N.
2004). Two-year outcome audit in an adult learning disability population with refractory epilepsy. Seizure, 13, 529–533. Shastry, B. S. (1997). On the functions of lithium: the mood stabilizer. BioEssays, 19, 199–200. Simister, R. , Sander, J. , & Koepp, M. J. (2007). Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability. Epilepsy & Behavior, 2, 336–339. Singh, B. , & White-Scott, S. (2002). Role of topiramate in adults with intractable epilepsy mental retardation and developmental disabilities.