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By Joseph F. Albright

George Washington Univ. college of drugs, Washington, D.C. Examines the most important gains and features of the immune method probably to be altered by means of the getting older technique. experiences the slow breakdown of the resistance to an infection within the elderly and discusses lifespan extension and dietary hold up of immunosenescence. DNLM: Immunity--Aged.

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Extra info for Aging, Immunity, and Infection

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FHA is a functionally complex molecule that displays several domains capable of interacting with complementary sites on host cells. These domains include: an N-terminal lectin domain that binds sialic acid and is required for hemagglutination; a lectin domain for ciliated host cells; a domain containing an arginine-glycine-asparagine (RGD) sequence that binds to the leukocyte integrin CR3 (CD11b/CD18) and two regions that resemble sites on factor X of the coagulation mechanism that also bind to leukocyte CR3 (33).

It appears that intimin not only interacts with Tir but also with β1 integrin molecules on T cells. The resulting hyperplastic changes in the gut provide further opportunities for EPEC colonization. This is an excellent example of the diversion of host immune defenses (T cells and their cytokines) into paths that promote the welfare of the bacterial pathogen. There are other outstanding cases such as that of S. typhimurium (47). In this case, the bacterium secretes proteins via a type III mechanism that Aging and Altered Resistance to Infection 33 Table 2-4 Some Interactions of Bacterial Lectins-glycoconjugates Bacteria Klebsiella pneumoniae Mycobacteria Salmonella Serratia marcescens Shigella flexneri Vibrio cholerae Streptococcus pyogenes Escherichia coli (urinary pathogens) Lectin type Type 1 & 3 Mycotin P-related (F7–F16) G-I G-II G-III Clostridium difficile Escherichia coli Streptococcus pneumoniae Escherichia coli (sepsis pathogen) Escherichia coli (urinary pathogen) Vibrio cholerae Helicobacter pylori Mycoplasma galliseptum; M.

Among the latter, those that convey multiple antibiotic resistance vary with respect to the transposons they contain. Some have a single transposon composed of multiple resistance determinants. Some have several transposons located in different sites. In some cases, there is present a complex element in which one transposon has become integrated into another. Apparently, there has been no effort to evaluate the R-plasmids present in bacterial 42 Aging, Immunity, and Infection isolates from older persons, especially those residing in LTCFs, to determine whether or not the plasmids and the resistance transposons differ from isolates obtained from young adults.

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